Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias

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Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias is written by Henry Sutanto and published by Henry Sutanto. It's available with International Standard Book Number or ISBN identification 946423105X (ISBN 10) and 9789464231052 (ISBN 13).

Cardiomyocyte calcium handling is a major determinant of excitation-contraction coupling. Alterations in one or more calcium-handling proteins may induce arrhythmias through the formation of ectopic activity, direct and indirect ion-channel regulation, and structural remodeling. Due to the complex and tight interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Multiscale computational studies performed in close collaboration with laboratory experiments create new opportunities to unravel the mechanisms of arrhythmogenesis. This thesis describes the roles of integrative computational modeling in unraveling the arrhythmogenic consequences of calcium-handling abnormalities.