Multiple Drug Resistance in Cancer

Know about the book -

Multiple Drug Resistance in Cancer is written by Martin Clynes and published by Springer Science & Business Media. It's available with International Standard Book Number or ISBN identification 9401108269 (ISBN 10) and 9789401108263 (ISBN 13).

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.