Advancing Methods for Biomolecular Crystallography

Know about the book -

Advancing Methods for Biomolecular Crystallography is written by Randy Read and published by Springer. It's available with International Standard Book Number or ISBN identification 9400762321 (ISBN 10) and 9789400762329 (ISBN 13).

This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.