Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

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Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy is written by Emmanuel Donnadieu and published by Springer. It's available with International Standard Book Number or ISBN identification 3319422235 (ISBN 10) and 9783319422237 (ISBN 13).

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.