Models of Viral Hepatitis

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Models of Viral Hepatitis is written by Fritz von Weizsäcker and published by Karger Medical and Scientific Publishers. It's available with International Standard Book Number or ISBN identification 3318011347 (ISBN 10) and 9783318011340 (ISBN 13).

Viral hepatitis B or C is the most common cause of chronic liver disease worldwide and accounts for about 80% of all hepatocellular carcinoma cases. Thus, combating viral hepatitis remains one of the most pressing public health issues today. Animal models and cell-based systems are essential tools for addressing the many still unresolved basic and clinical problems. Experimental models are needed to better understand the viral life cycles, pathogenetic aspects and natural defense mechanisms, while preclinical models are required for evaluating novel preemptive and therapeutic strategies. This monograph provides a unique synopsis of currently available models of viral hepatitis, highlighting their particular use for basic and translational science. Leading experts discuss new scientific results and evolving methods in various animal and in vitro models, including the woodchuck, duck, mouse, chimpanzee and tupaia, as well as primary hepatocytes and subgenomic HCV replicons. A valuable single source of information, this book will be of interest to all investigators and clinicians working in the fields of viral hepatitis and/or hepatology.