Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
- Eugenio Barone
- Mara Dierssen
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Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap! is written by Eugenio Barone and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2889634574 (ISBN 10) and 9782889634576 (ISBN 13).
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
