Evolution of Genetic Mechanisms of Antibiotic Resistance

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Evolution of Genetic Mechanisms of Antibiotic Resistance is written by Silvia Buroni and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2889632229 (ISBN 10) and 9782889632220 (ISBN 13).

Since the first introduction of antibiotics into clinical practice, microbial drug resistance has emerged as a major obstacle in the treatment of infections. Recently, the combination of emergence of a complex variety of multidrug resistant strains and the dearth of newly discovered molecules to effectively target and eliminate these strains, has made antibiotic resistance one of the major public health problems of this century. Although different strategies can be adopted to contain the emergence and spread of antibiotic resistance, including (i) antimicrobial stewardship, (ii) infection control, and (iii) tighter control over the use of antibiotics in agriculture and breeding, a better understanding of the dynamics that lead to the evolution of antibiotic resistance remains essential for the development of more efficient strategies to combat this phenomenon. The recent developments in genomics have greatly contributed to expand our knowledge on the mechanisms of microbial resistance, and of the processes by which they emerge, develop and spread. Different approaches and expertise can be used to accelerate advances in this area, ranging from clinical studies on the evolution of resistance in vivo, to theoretical modeling and the study of evolution in the laboratory.