Linking the Endocrine System With Immunity

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Linking the Endocrine System With Immunity is written by Dorota Latek and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832567681 (ISBN 10) and 9782832567685 (ISBN 13).

An adequate and balanced response to pathogenic factors is one of the conditions that determine the survival of an individual, a population, or even an entire species. Clinical data collected during the COVID-19 pandemic showed that a patients’ resistance varied, depending on their levels of well-known endocrine system regulators, e.g., vitamin D. In addition, the imbalance of hormonal milieu in women increases the prevalence rate for autoimmune diseases compared to men, whilst exposure to endocrine disruptors negatively affects the development of the immune system in offspring leading to later health defects. All of the above proves that understanding the linkage between the endocrine and immune system is necessary to propose new therapeutic strategies helping improve the lives of those with disease and illness. It is known that restoring the endocrine system balance through ligand-mediated modulation of GPCR signaling improves the functioning of both innate and adaptive immune systems. Thus, an excessive immune response demonstrated that acute or chronic inflammation can be controlled differently than through commonly used immunosuppressive drugs. There is therefore much more to be discovered from learning the relationship between these two systems.