Cancer Plasticity and The Microenvironment: Implications for Immunity and Therapy Response, volume II

Know about the book -

Cancer Plasticity and The Microenvironment: Implications for Immunity and Therapy Response, volume II is written by Petranel Theresa Ferrao and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 283256741X (ISBN 10) and 9782832567418 (ISBN 13).

The field of cancer research has been significantly impacted by the discovery of cellular plasticity mechanisms, which allow cancer cells to modify their phenotype and function. This adaptability not only influences the tumour microenvironment (TME) but is also affected by it. The ability of cancer cells to change has been linked to dormancy, tumour progression, metastasis, immune evasion, and treatment resistance. The dynamic relationship between cancer cells and 'normal' cells within the TME contributes to the shaping of each other, affecting treatment outcomes. Therefore, understanding the interactions between tumour cells and TME cells that drive plasticity is crucial for addressing therapeutic resistance. This research topic aims to delve deeper into the cross-talk between cancer cells and other cells within the TME. It seeks to explore the role of cell-intrinsic and cell-extrinsic factors in tumour plasticity, including the patient's innate immunity, local and systemic inflammation levels, microbiome balance, and the impact of stress. The research also aims to understand the heterogeneity within tumours and across patients, as well as the adaptive changes that occur within the tumour and patient, including those resulting from cancer treatments that can contribute to cross-resistance.