Cardiovascular Diseases Related to Diabetes and Obesity, volume V

Know about the book -

Cardiovascular Diseases Related to Diabetes and Obesity, volume V is written by Ying Xin and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832567339 (ISBN 10) and 9782832567333 (ISBN 13).

Given the success of the previous collection, Cardiovascular Diseases Related to Diabetes and Obesity - Volume IV, and the new advances in the field, we are pleased to announce the launch of Volume V. The dramatic increase in the prevalence of diabetes, obesity, and metabolic syndrome worldwide has seriously threatened human health since its associated complications cause high morbidity and mortality. Among the complications, cardiovascular diseases are the predominant component. Although various controls for blood glucose and blood pressure are applied, patients with diabetes or obesity and associated metabolic syndromes are still at high risk of developing various cardiovascular diseases, nephropathy, retinopathy, neuropathy, skin disorders, and male infertility. Therefore, we need to understand the mechanisms underlying the pathogenesis of these complications in order to develop more effective therapies to prevent or slow down the progression of diabetic or metabolic syndrome complications. One of the underlying mechanisms for these cardiovascular diseases is oxidative stress, a critical role in the pathogenesis of diabetic complications. Diabetes-induced overproduction of mitochondrial superoxide leads to a series of detrimental cellular events, including the increased formation of advanced glycation end products (AGEs), increased expression of the receptor for AGEs (RAGE), and activation of protein kinase C isoforms, the polyol pathway, and the hexosamine pathway. These effects consequently result in pathological remodeling of the end-organs and their dysfunction. Hence, targeting diabetes-induced oxidative stress has attracted much research interest in recent years.