Functional Neuroendocrine Tumors

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Functional Neuroendocrine Tumors is written by Bojana Popovic and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832566790 (ISBN 10) and 9782832566794 (ISBN 13).

One of authentic features of neuroendocrine tumors (NETs) is a potential to synthesize and secrete biogenic peptides and hormones. Typically arising from tumors originating from the pancreas, lungs and intestine, these products can cause recognizable clinical hormone syndromes. Even rarer among the rare, functional NETs are in the minority compared to nonfunctional tumors (i.e. 10-40% in a group of pancreatic NETs), but they represent great diagnostic and therapeutic challenges. For any case of functional NET, hormonal hypersecretion syndrome causes excess morbidity, sometimes even more threatening than the cancer itself. This makes control of hormonal hypersecretion not only additional, but sometimes in fact a primary therapeutic goal. On the other hand, secretory product(s) can be useful as tumor markers and facilitate monitoring of treatment response. Unfortunately, many of these tumors become refractory to treatment over time, and new modalities are required.