Community Series in the Role of Complement in Health and Disease, volume II

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Community Series in the Role of Complement in Health and Disease, volume II is written by Maciej Cedzynski and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832566634 (ISBN 10) and 9782832566633 (ISBN 13).

The complement system is a crucial mediator of the innate immune response, interacting with other innate mechanisms and with factors of acquired immunity. It contributes significantly to cell homeostasis, tissue development and repair, reproduction, and cross-talk with other endogenous cascades. Each of the three major complement activation pathways (Classical, CP; Alternative, AP and Lectin, LP) employs specific recognition molecules and initiating serine proteases. All of them converge into a common pathway, leading to the formation of the biologically highly active anaphylatoxin C5a and the C5b-9 membrane attack complex (MAC). The latter forms transmembrane channels which either induce “sub-lytic” activation of the cell or result in target cell lysis. Although the complement system was discovered in 1888, nowadays this system is still under intense investigation with ongoing advances being made in various aspects including its clinical significance and its involvement in the regulation of the immune response.