Adrenal Related Hypertension: From Bench to Bedside, volume II

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Adrenal Related Hypertension: From Bench to Bedside, volume II is written by Elena Aisha Azizan and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832566235 (ISBN 10) and 9782832566237 (ISBN 13).

More than a third of the adult population worldwide has hypertension, a key risk factor for cardiovascular diseases and death. Although the majority of hypertension cases are idiopathic, approximately one in six hypertensive patients have secondary hypertension whereby an identifiable condition has led to raised blood pressure. Of these, 2-3% are estimated to have so-called endocrine hypertension due to an imbalance of hormone production in the adrenal. Diagnosis of adrenal-related endocrine hypertension is favourable as surgery and specific medical treatment are available. Despite the knowledge on adrenal-related endocrine hypertension, less than 1% of patients are currently diagnosed and only a handful of patients are completely cured by adrenalectomy surgery. Additionally, although many mutations have been found to be causal for adrenal-related endocrine hypertension (e.g. KCNJ5 mutations for primary aldosteronism, SDHB mutations for phaeochromocytoma, and ARMC5 mutations in Macronodular Adrenal Hyperplasia), the mechanisms involved are still not fully explained, and there are still adrenal lesions causing endocrine hypertension where the genetic caused is still undefined