The Role of Post-translational Modifications in Cancer Biology

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The Role of Post-translational Modifications in Cancer Biology is written by Arun Kumar Trivedi and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832564739 (ISBN 10) and 9782832564738 (ISBN 13).

Post translational modifications (PTMs) of a protein significantly impact on its structure and function which may have distinct ramifications in the biology of health and disease. Protein methylation may contribute to tumor suppressor activity, whereas histone acetylation can finely tune the genes response. Phosphorylation and SUMOylating of a protein may either enhance or mitigate their activity and play a role in their sub-compartmentalization within cell. Ubiquitination of proteins on the other hand though majorly drives their degradation, it may also impact their functionality. Abnormal status of any of these PTMs is frequently involved in cancer. Therefore, an integrative and deeper understanding of PTMs and their association with cancer pathology is important for therapeutical application for better treatment outcomes. A precise characterization of PTMs is important for the understanding of protein regulatory mechanisms and their role in disease. However, experimental studies focusing on such PTMs of key oncogenic factors are very limited. The aim of this Research Topic is to provide a deeper insight into basic, translational, and clinical research of protein modifications.