Tuberculosis diagnosis, drug resistance, and drug target discovery

Know about the book -

Tuberculosis diagnosis, drug resistance, and drug target discovery is written by Robert Jansen and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832563864 (ISBN 10) and 9782832563861 (ISBN 13).

Tuberculosis (TB) threatens global public health and remains one of the major infectious diseases worldwide. Effective detection and treatment of both drug-sensitive and drug-resistant TB are key challenges in the fight against TB. Currently, only about 50% of the WHO target TB cases are detected and only 30-40% of drug-resistant TB cases are recognized. Treatment success rates are approximately 85% for drug-sensitive TB and drop to only ~60% for multi-drug resistant TB (MDR-TB) on average worldwide. Early detection of TB cases is the first step to providing patients with appropriate treatment. Recognizing drug-resistant TB is more challenging and requires quick and accurate drug susceptibility test (DST) methods. In addition to improved diagnosis and DST, the discovery of new drug targets is crucial for TB control. This Research Topic focusses on TB and drug-resistance diagnosis, and drug target discovery. It aims to explore novel TB diagnosis methods to quickly find TB cases and recognize drug-resistance. DST for anti-TB drugs is also essential to guide the further diagnosis of drug-resistant TB, how to evaluate and compare them, and establish new DST methods to further guide clinics to use rationally is the other purpose under this topic. At the same time, this Research Topic aims to explore new drug resistance mechanisms and tools to study drug resistance. Finally, it explores new drug targets and tools to study them.