Enhancing T Cell Function: Innovations in Cancer Immunotherapy

Know about the book -

Enhancing T Cell Function: Innovations in Cancer Immunotherapy is written by Xuefeng Wang and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832563538 (ISBN 10) and 9782832563533 (ISBN 13).

Cancer immunotherapy has been revolutionized by targeting specific immune subsets within the tumor microenvironment, where T cells play a pivotal role. Gene-engineered T cell strategies and immune checkpoint blockade (ICB) therapies have emerged as powerful approaches to reinvigorate tumor-infiltrating T cells, demonstrating considerable promise in clinical outcomes. However, challenges persist, particularly the limited in vivo persistence of adoptively transferred T cells and the variable patient response rates to ICB therapy. Key barriers include T cell exhaustion and the immunosuppressive milieu of the tumor microenvironment. Consequently, a deep understanding of functional modulation of these immune subsets is urgently needed to enhance the efficacy and safety of various T cell therapies, such as Tumor-infiltrating T lymphocytes (TIL-T), T cell receptor-engineered T cells (TCR-T), and Chimeric antigen receptor T cells (CAR-T). This Research Topic aims to explore and identify crucial targets and pathways for overcoming immune dysregulation in the tumor microenvironment. We seek to advance our understanding of these complexities by discussing innovative techniques that could augment T cell antitumor functionality. Contributions that unveil novel approaches or refine existing methods to boost the therapeutic potential of T cells in cancer treatment are particularly encouraged.