Multi-omics Application in Exploring Potential Biomarkers Targeting Resistance of Anti-Cancer Drugs

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Multi-omics Application in Exploring Potential Biomarkers Targeting Resistance of Anti-Cancer Drugs is written by Hailin Tang and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832562884 (ISBN 10) and 9782832562888 (ISBN 13).

Cancer remains a critical concern in global health due to its high prevalence and mortality rates. Despite significant advancements in the development of anti-cancer drugs, drug resistance continues to pose a major challenge in clinical treatments. Drug resistance may be either intrinsic i.e., pre-existent resistance present in the tumor cells even before exposure to chemotherapy, or acquired resistance i.e., induced by drugs during or after treatment of tumors with anticancer compounds. Anti-cancer treatments such as chemotherapy, targeted therapy, and immunotherapy are highly genotype-related interventions. Coding and Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), lncRNAs, circular RNAs (circRNAs), and PIWI-RNA (piRNA) have been shown to play important roles in tumor formation and therapeutic resistance. lncRNAs can activate DNA damage repair, silence tumor suppressor genes, and modulate cancer-related epigenetic changes at the chromatin level in terms of histone modifications, DNA methylation, and altering chromatin architecture.