Gut Microbiota in Health and Disease

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Gut Microbiota in Health and Disease is written by Diogo Alpuim Costa and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832560938 (ISBN 10) and 9782832560938 (ISBN 13).

Gut microbiota plays a crucial role in host health maintenance and disease pathogenesis. The largest reservoir of microbiota exists in gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. Dysbiosis is associated with decreased microbiota function and diversity, disrupted epithelial barrier, bacterial translocation, inflammation, and local/systemic microbial-driven immunomodulation. In fact, gut dysbiosis appears to be associated with increased risk of developing inflammatory, autoimmune, and malignant diseases. In addition, it is important to explore implications of microbiota variations on drug disposition, action and toxicity.