Impact of the Innate and Adaptive Immune System in Driving Type 1 Inflammatory Skin Disease

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Impact of the Innate and Adaptive Immune System in Driving Type 1 Inflammatory Skin Disease is written by Barbara Meier-Schiesser and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832560482 (ISBN 10) and 9782832560488 (ISBN 13).

Inflammatory skin diseases are frequent in number and often lead to a decreased quality of life in the affected patients. These diseases result from a complex interplay between the innate and adaptive immune systems. Type 1 inflammation is an immune response driven primarily by Th1 cells, which secrete pro-inflammatory cytokines, notably Interferon-gamma. The initiation of Type 1 inflammation is typically triggered by the recognition of antigens associated with intracellular pathogens. Dendritic cells present these antigens to naive T-cells, leading to the differentiation of predominantly Th1 cells, which in turn activate other immune cells, including macrophages and cytotoxic T-cells. In chronic inflammation, the infiltration of T cells drives the perpetuating cycle of inflammation at the epidermal barrier. Th1-induced inflammation can synergize with recruitment and heightened activity of other T cell subsets such as Th17 cells. Typical type 1 inflammatory skin diseases include psoriasis, lichen planus, acne, hidradenitis suppurativa, pityriasis rubra pilaris, adverse cutaneous drug eruptions, and autoimmune disorders such as vitiligo and lupus erythematodes.