Cancer Pathogenesis: Molecular and Cellular Mechanisms of Tumor evolution, Therapy-Resistance and Immune Evasion

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Cancer Pathogenesis: Molecular and Cellular Mechanisms of Tumor evolution, Therapy-Resistance and Immune Evasion is written by Sambhavi Animesh and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832559336 (ISBN 10) and 9782832559338 (ISBN 13).

Cancer pathogenesis is a pathophysiological understanding of how molecular and cellular events play a causal role in transforming tumors from benign to malignant state. This often involves genetic, epigenetic, proteomic and metabolic alterations within solid tumors and blood cells. Besides cell intrinsic factors, tumors are also composed of stromal fibroblasts, blood vessel and immune cells that are also implicated in tumor progression. Immune evasion is another critical step of the cancer progression, wherein tumor cells modulate host immune system to escape from getting destroyed. Additionally, stemness in cancer cells is another acquired intrinsic ability of self-renewal, differentiation, heterogeneity and survival. Such properties give an edge to the tumors to maintain malignancy and confers treatment resistance. Most anti-cancer therapies that trigger cell death, senescence and/or dormancy and may backfire into maladaptive responses that lead to therapy resistance and promote tumor progression. Together these highlight the most challenging issues of cancer pathogenesis. This Research Topic aims to summarize the cutting-edge research for the broader understanding of the molecular and cellular determinants involved in cancer initiation and progression, and their impact on the anti-tumor therapies and immune evasion. In summary, this topic will help researchers to gain a more comprehensive understanding of the cancer pathogenesis, which can be used further in the development of novel therapies.