Spotlighting the Interaction Network of Hub Genes, Molecules, and Cells in the Tumor Immune Microenvironment (TIME) and their Contribution to Malignant Progression

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Spotlighting the Interaction Network of Hub Genes, Molecules, and Cells in the Tumor Immune Microenvironment (TIME) and their Contribution to Malignant Progression is written by Xuanbin Wang and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832558321 (ISBN 10) and 9782832558324 (ISBN 13).

The tumor immune microenvironment (TIME) is a complex network of interactions between cancer cells, immune cells, and other stromal cells. Dysregulation of this network can promote tumor progression and immune evasion. Several key molecules, such as cytokines, chemokines, and growth factors, play critical roles in modulating the interactions between immune cells and tumor cells within the TIME. Regulation of these key molecules is tightly controlled by multiple feedback loops and signaling pathways, both within and between immune cells and tumor cells. On the other hand, immune cells such as T cells, natural killer (NK) cells, and dendritic cells (DCs) can also produce cytokines that activate or inhibit other immune cells and recruit additional immune cells to the TIME. The crosstalk between different immune cells within the TIME is critical for the regulation of immune responses and tumor progression. However, tumor cells can also exploit these interactions to evade immune surveillance and promote their own growth and survival. Overall, the regulation of key molecules in the TIME and the crosstalk between immune cells are critical for the maintenance of immune homeostasis and the prevention of tumor progression. Dysregulation of this network can promote immune evasion and tumor growth, highlighting the importance of developing targeted therapies that can modulate the interactions between immune cells and tumor cells within the TIME. The objective of our topic collection is to explore the network regulation of key molecules in the TIME and the crosstalk between immune cells and tumor cells in relation to tumor progression. Specifically, the scope will focus on the role of cytokines, chemokines, immune checkpoints, and antigen-presenting molecules in the regulation of the TIME and the mechanisms by which these molecules interact with immune cells to promote or inhibit tumor growth. Additionally, this topic scope aims to investigate the potential of targeting these key molecules and their regulatory pathways for cancer immunotherapy. Through this exploration, our topic collection seeks to provide a comprehensive understanding of the complex interactions between immune cells and tumor cells in the TIME, which may lead to the development of novel strategies for cancer treatment.