In Vitro Diagnosis of Allergic and Mast Cell-Related Disorders

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In Vitro Diagnosis of Allergic and Mast Cell-Related Disorders is written by Joana Vitte and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832556841 (ISBN 10) and 9782832556849 (ISBN 13).

Allergic diseases, affecting one in four people, are diagnosed through the demonstration of an abnormal immune response (sensitization) to a trigger (allergen) inducing a clinical hypersensitivity response. Allergen-induced immune responses can be demonstrated using in vivo (skin and challenge), or in vitro tests. The occurrence and severity of hypersensitivity reactions are influenced by mast cell disorders, such as hereditary alpha-tryptasemia, which is found in up to 8% of general population by means of serum tryptase measurement. The place of in vitro tests has considerably expanded since the beginning of the century, thanks to progress in multiple fields including allergen biochemistry, pathophysiological research, methodological innovation, cohort studies, and statistics tools. 21st century in vitro tools are exquisitely quantitative and standardized, allowing for reliable comparison and follow-up of allergic patients. They are also miniaturized, with hundreds or even thousands of biomarkers assayed in minute volumes of biological fluids, and they are increasingly non-invasive or minimally invasive, allowing for better testing of children. Moreover, new regulation applicable to in vivo tests tends to decrease the available number of preparations, while newly commercialized allergens are often available as in vitro tests.