Single-cell analysis on the pathophysiology of autoimmune diseases

Know about the book -

Single-cell analysis on the pathophysiology of autoimmune diseases is written by Shiang-Jong Tzeng and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832551637 (ISBN 10) and 9782832551639 (ISBN 13).

Despite increasing research to facilitate the understanding of the pathophysiology of autoimmune disorders, the exact cause of the incident of autoimmunity is unknown. Current concepts on the occurrence of autoimmune diseases are thought to involve autoantigens, genetic predisposition, disease triggers, and the breakdown of immune tolerance. In addition to the breakdown of immunological tolerance, one key characteristic of autoimmune disease is that within a single disease there is considerable variability in the clinical manifestation and severity in patients. Single-cell omics have emerged as an effective means of unraveling the complexity and heterogeneity of chronic disease development and therapeutic responses. Recently, advances in cutting-edge spatial profiling of diverse cell types have increased our understanding of how distinct cells interact and orchestrate at specific locations across a tissue landscape in both physiological and pathological contexts at the single-cell level.