Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond

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Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond is written by Whitney Yin and published by Frontiers Media SA. It's available with International Standard Book Number or ISBN identification 2832503829 (ISBN 10) and 9782832503829 (ISBN 13).

olymerases are the nucleotidyl transferases that are responsible for synthesizing DNA and RNA. They are crucial for essential cellular processes including cellular and viral genome replication, DNA repair and damage tolerance, and transcription. Consistent with their vital roles, polymerases are found in all domains of life. The overall chemistry employed by these enzymes is conserved but there are variations among the different groups of polymerases that confer different substrate specificities and nucleotide incorporation fidelities that allow them to be involved in a wide array of cellular activities. Since polymerases were first isolated more than six decades ago, we have made great progress in understanding how different polymerases have adapted to their specific roles. In this Research Topic we will focus on the enzymatic mechanisms of these enzymes and the relationships between polymerase structure and mechanism, to highlight common themes and unique adaptations.